SynBBB Blood-Brain-Barrier-on-a-Chip
Recreate physiologically relevant normal and dysfunctional Blood-Brain-Barrier models
SynBBB Idealized Linear Chip
SynBBB Idealized Radial Chip
SynBBB Idealized Radial TEER Chip
SynBBB 3-PLEX linear Chip
SynBBB™ Blood Brain Barrier (BBB) on-a-Chip recreates an in vivo like BBB with brain endothelial cells, astrocytes and pericytes with physiological flow modeling blood flow and shear stress. SynBBB can be used to detect permeability of compounds from small molecules to biologics. Measure antibody or viral transport across the BBB using receptor mediated transcytosis assays. Measure drug or inflammation induced BBB injury and test drugs that repair a leaky BBB. Model neuroinflammation and screen anti-inflammatory therapeutics.
Complete lumen formed with hCMEC/D3 brain endothelial cell line in SynBBB co-culture model
Human BBB-on-a-Chip with primary brain endothelial cells/pericytes/astrocytes
Applications and Assays
Publications using SynBBB models
Contract Research Services using SynBBB models
Screen for drug transport, safety, efficacy and more..
SynBBB Models Available
Human BBB-on-a-Chip
- Primary cell based tri-culture BBB model – brain endothelial cells, astrocytes and pericytes
- iPSC-derived tri-culture BBB model with human brain endothelial cells, astrocytes and pericytes
- Cell line based tri-culture BBB model with hCMEC/D3 brain endothelial cell line, primary astrocytes and pericytes
Human BBTB-Barrier-on-a-Chip (Blood-Brain-Tumor-Barrier)
- Brain endothelial cells, astrocytes+glioblastoma
- Brain endothelial cells, tumor cells
Rodent BBB-on-a-chip also available
Sample SynBBB Assays
Drug Transport:
- Real-time permeability of small molecules to biologics
- Receptor-mediated Transcytosis of antibodies and viruses
NeuroInflammation
- Detect drug or disease induced inflammation with immune cell adhesion and migration assays, permeability and TEER
Neuroprotection
- Evaluate drugs that repair the BBB
- Screen with anti-inflammatory therapeutics
Neurotoxicity
- Detect drug or disease induced vascular toxicity
Efficacy
- CAR-T based tumor killing with Blood-Brain-Tumor-Barrier model
Brochures and Technical Manuals
Videos
Purchase SynBBB Products and Instruments
Purchase starter kits, sets of chips, brain cells/cell lines, instrumentation and training workshops
SynBBB Starter Kit: Select this for your first-time purchase. All the basic components required to run SynBBB assays can be purchased in a kit format. The SynBBB starter kit includes 12 chips, tubing, clamps, needles, syringes, pneumatic priming device and the cell impedance analyzer (TEER configuration only).
SynBBB Chip Options: Depending on your specific research applications you can select from Linear, Radial or TEER Chip configurations.
Cells/Cell Lines: SynVivo offers human brain cells and cell lines that have been tested and validated in the BBB model.
Instrumentation: Syringe Pumps for cell seeding and maintaining flow based assays, stage top Incubator and inverted microscope for real time visualization and quantitation of your BBB assays
Training Workshops: SynVivo offers 2 and 4 day scientist-led training sessions. Gain hands on experience with our organ-on-a-chip technology
SynBBB Starter Kits - Select your BBB chip
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Chip Model | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
 | 402014 | $2,100 | |||
 | 402002 | $2,100 | |||
 | 402006 | $2,100 | |||
 | 402004 | $3,600 |
SynBBB Model Chips
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Chip Model | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
| 102003-SB3 | $375 | |||
| 108011-SB3 | $375 | |||
| 102015-SB3 | $550 | |||
 | 102005-SB3 | $375 |
Validated Brain Cells (Primary and Immortalized)
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CAT # | Product Name | Price | Qty | |
|---|---|---|---|---|
Syn-10HU-051 | $885 | |||
Syn-CLU512 | $1,200 | |||
Syn-10HU-035 | $839 | |||
Syn-10HU-031 | $1,018 |
Training Workshops
Syringe Pumps - Instrumentation for Seeding Cells and Maintaining Flow Based Assays
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Image | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
 | 301004 | PHD Ultra 6/10 Multi Syringe Rack | $920 | ||
 | 301020 | Multichannel Programmable Syringe Pump – SynVivo NE 1200 | $2,100 | ||
 | 301002 | Pump 11 Elite Nanomite Infusion/Withdrawal Programmable Single Syringe | $3,790 | ||
 | 301003 | PHD Ultra Syringe Pump Programmable 2-Syringe Rack Standard Pressure | $5,651 |
Tokai Hit Stage Top Incubators
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Image | CAT# | Product Name | Contact Us |
|---|---|---|---|
 | 303015 | ||
| 303016 | ||
| 303017 |