SynOcu™ Cornea-on-a-Chip
Human-Relevant Model for Corneal Drug Transport, Safety & Efficacy Under Physiological Flow
SynOcu Cornea-on-a-Chip
SynOcu™ is a dynamic, microfluidic Cornea-on-a-Chip platform designed to mimic native human corneal architecture and barrier function. Using physiologically realistic flow, SynOcu enables direct, real-time visualization of drug transport across the corneal layers—making it ideal for ophthalmic drug development, delivery optimization, and safety studies.
Key Features:
- Tri-culture of epithelial, stromal, and endothelial cells
- Real-time flow-based modeling of tear film and aqueous humor
- Modularity to add conjunctiva and simulate dual delivery routes
- Maintains native phenotype with validated morphology & marker expression
- Compatible with imaging and high-content readouts
Applications:
- Drug permeability & transport assays
- Antibody-drug conjugate (ADC) ocular toxicity
- Safety pharmacology & cytotoxicity
- Ophthalmic formulation optimization
- Nanoparticle drug delivery
Why SynOcu™ Outperforms Traditional Models
- Dynamic flow mimics tear and aqueous humor
- Human cell-based, animal-free design
- Tri-layer complexity in a single chip
- Imaging-compatible and automation-ready
- Expandable to conjunctiva and other ocular tissue
Cornea-on-a-Chip Model Characterization
Performance That Mirrors Human Physiology
Marker Expression
CK3 stratification marker increases under flow supporting epithelial maturation.
Barrier Integrity
Small molecule permeability significantly decreases from mono- to tri-culture, mimicking in vivo tight junctions.
Physiological Transport
SynOcu’s flow-based model more closely mimics paracellular transport in human tissue than static Transwell inserts.
Contact our scientists to find out how SynOcu™ can accelerate your drug development with human-relevant data.
Contract Research Services
SynOcu™ Cornea-on-a-Chip: Comprehensive Services for Ocular Drug Development
SynVivo offers expert-led contract research services (CRO) leveraging the SynOcu™ platform for advanced ocular drug development. Our team supports end-to-end study design, execution, and analysis to meet your safety, efficacy, and delivery objectives without the limitations of animal models.
Examples of Services Offering
- Drug Transport
- Quantitative assessment of ocular permeability
- Evaluate drug penetration across human-relevant corneal barrier
- Drug Safety
- Detection of cytotoxicity and barrier integrity loss
- Early-stage safety profiling of small molecules, biologics, and ADCs
- Drug Efficacy
- Measure therapeutic effect on inflamed or injured corneal models
- Support for proof-of-concept and comparative studies
- ADC Testing
- Specific evaluation of antibody-drug conjugates for ocular toxicity and transport
- Identify corneal safety risks of targeted therapies
Starter Kits - Cornea chip model
Important Note: Starter kit does not include required consumables such as cells, media, and matrix. Other required equipment not included is syringe pumps, cell seeding pumps, incubators, and microscopes.
SynOcu™ Starter Kit: Start your cornea-on-chip research with ease using the SynOcu™ Starter Kit.
Includes:
- Microfluidic SynOcu Cornea chips (12)
- Pneumatic priming device
- Tubing, clamps, needles, and syringes
- Multiple Port Manifold
The Cornea Model kit features a disposable, optically transparent chip that supports studies of trans-corneal transport under physiological flow conditions
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Chip Model | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
 | 501000 | $3,650 |
SynOcu Model Chip
SynOcu™ Chip Option: The chip architecture best suits your cornea application:
- Cornea Chip – Ideal for Drug safety, Drug Delivery, and Toxicity assays
The cornea chip modular design recreates 3D human-relevant trans-corneal transport conditions under physiological flow, delivering real-time quantitative analysis .
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Chip Model | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
| 109001-SO3 | $690 |
Training Workshops
Training Workshops: Accelerate proficiency with SynVivo’s expert-led programs:
- 2-Day Intro Workshop – Focused on setup, ALI maintenance, and basic functional assays
- 4-Day Advanced Workshop – Covers immune interaction assays, mucus and ciliary function, drug testing workflows, and mechanistic modeling
Syringe Pumps - Instrumentation for Seeding Cells and Maintaining Flow Based Assays
Instrumentation: Ensure high-quality results with SynVivo-compatible tools:
- Syringe pumps for precise flow control
- Stage-top incubators and inverted microscopes for real-time imaging of ciliary beating, mucus flow, and drug deliver
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Image | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
 | 301004 | PHD Ultra 6/10 Multi Syringe Rack | $948 | ||
 | 301020 | Multichannel Programmable Syringe Pump – SynVivo NE 1200 | $2,100 | ||
 | 301002 | Pump 11 Elite Nanomite Infusion/Withdrawal Programmable Single Syringe | $3,790 | ||
 | 301003 | PHD Ultra Syringe Pump Programmable 2-Syringe Rack Standard Pressure | $5,651 |
Tokai Hit Stage Top Incubators
The Tokai Hit incubator offers precision temperature, humidity and CO2 control for long term cell culture on any microscope and optimal conditions for SynVivo’s microfluidic devices.
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Image | CAT# | Product Name | Contact Us |
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 | 303015 | ||
| 303016 | ||
| 303017 |