NEW! SynTEER™ Multiplexed Organ-on-Chip Models
Smarter Chips – Simpler TEER
SynTEER Multiplexed Chip
Integrated electrode design
SynVivo’s SynTEER™ model has integrated TEER electrodes engineered directly within the multiplex chip architecture. This unique design allows for convenient non-invasive determination of TEER in multiple devices simultaneously enabling confirmation of mature barrier formation and detection of barrier disruption within minutes of compound exposure.
SynTEER™ Advantages
- Real-Time Barrier Analysis – Monitor barrier formation, maturation, and disruption dynamically with integrated TEER sensing directly within the microfluidic chip architecture.
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Integrated Electrode Design – Embedded electrodes eliminate cumbersome external electrode positioning while improving consistency and ease of use.
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Rapid Detection of Compound Effects – Identify barrier disruption within minutes of compound exposure, enabling faster assessment of drug response, toxicity, and inflammation.
Learn More about the SynBBB Blood-Brain-Barrier Model
Complete lumen formed with hCMEC/D3 brain endothelial cell line in SynBBB co-culture model
Human BBB-on-a-Chip with primary brain endothelial cells/pericytes/astrocytes
Applications and Assays
Contract Research Services using SynTEER models
Screen for drug transport, safety, efficacy and more..
SynTEER Models Available
Human BBB-on-Chip
- Primary cell based tri-culture BBB model – brain endothelial cells, astrocytes and pericytes
- iPSC-derived tri-culture BBB model with human brain endothelial cells, astrocytes and pericytes
- Cell line based tri-culture BBB model with hCMEC/D3 brain endothelial cell line, primary astrocytes and pericytes
Human BBTB-Barrier-on-Chip (Blood-Brain-Tumor-Barrier)
- Brain endothelial cells, astrocytes + glioblastoma
- Brain endothelial cells, tumor cells
Intestine-on-Chip
- Small intestine endothelial cells and epithelial cells co-cultured
Inflammation-on-Chip
- SynRAM architecture utilizing primary endothelial cells with a pro-inflammatory insult such as a cytokine
Sample SynTEER Assays
Drug Transport:
- Real-time permeability of small molecules to biologics
- Receptor-mediated Transcytosis of antibodies and viruses
NeuroInflammation
- Detect drug or disease induced inflammation with immune cell adhesion and migration assays, permeability and TEER
Neuroprotection
- Evaluate drugs that repair the BBB
- Screen with anti-inflammatory therapeutics
Neurotoxicity
- Detect drug or disease induced vascular toxicity
Efficacy
- CAR-T based tumor killing with Blood-Brain-Tumor-Barrier model
Purchase SynTEER Products and Instruments
Purchase starter kits, sets of chips, cells/cell lines, instrumentation and training workshops
SynTEER Starter Kit
The SynTEER Starter Kit is the fastest way to launch your in vitro barrier tissue assays. Designed for first-time and experienced users alike, it includes the core components needed for setup and operation across a wide range of epithelial and endothelial applications.
Kit Includes:
- 8 SynTEER Multiplexed Chips (with embedded electrodes)
- Tubing, clamps, needles, and syringes
- Pneumatic priming device for bubble free functionalized models
- SynVivo Impedance Analyzer and chip probe
This complete package enables rapid deployment of permeability, transport, toxicity, and barrier integrity assays in physiologically relevant in vitro models.
Important Note: Starter kit does not include required consumables such as cells, media, and matrix. Additional required equipment not included: syringe pumps, cell seeding pumps, incubators, and microscopes
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CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|
402016 | $8,250 |
SynTEER Embedded Electrode Chip
3PLEX TEER Configuration – TEER-enabled setup with impedance analyzer for non-invasive, real-time barrier integrity monitoring during tight junction formation, injury, and recovery
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Chip Model | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
 | 105016-STE8 | $4,500 |
Human Cells/Cell Lines
Cells & Cell Lines: SynVivo provides validated and customizable cell options to support a wide range of SynTEER barrier and organ-on-chip applications:
- Primary human cells and validated cell lines for epithelial, endothelial, and other barrier models, including blood-brain barrier (BBB) applications
- Co-culture options with relevant supporting or immune cell types to model complex tissue responses
- Custom cell sourcing available for disease-specific, translational, and specialized research applications
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CAT # | Product Name | Price | Qty | |
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Syn-10HU-051 | $885 | |||
Syn-CLU512 | $1,499 | |||
Syn-10HU-035 | $1,081 | |||
Syn-10HU-031 | $1,018 |
Training Workshops
Training Workshops: Accelerate proficiency with SynVivo’s expert-led programs:
- 2-Day Intro Workshop – Focused on setup, ALI maintenance, and basic functional assays
- 4-Day Advanced Workshop – Covers immune interaction assays, mucus and ciliary function, drug testing workflows, and mechanistic modeling
Syringe Pumps - Instrumentation for Seeding Cells and Maintaining Flow Based Assays
Instrumentation: Ensure high-quality results with SynVivo-compatible tools:
- Syringe pumps for precise flow control
- Stage-top incubators and inverted microscopes for real-time imaging of ciliary beating, mucus flow, and drug deliver
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Image | CAT# | Product Name | Price | Qty | |
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 | 301004 | PHD Ultra 6/10 Multi Syringe Rack | $948 | ||
 | 301020 | Multichannel Programmable Syringe Pump – SynVivo NE 1200 | $2,100 | ||
 | 301002 | Pump 11 Elite Nanomite Infusion/Withdrawal Programmable Single Syringe | $3,790 | ||
 | 301003 | PHD Ultra Syringe Pump Programmable 2-Syringe Rack Standard Pressure | $5,651 |
Tokai Hit Stage Top Incubators
The Tokai Hit incubator offers precision temperature, humidity and CO2 control for long term cell culture on any microscope and optimal conditions for SynVivo’s microfluidic devices.
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Image | CAT# | Product Name | Contact Us |
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 | 303015 | ||
| 303016 | ||
| 303017 |