SynTox™ Toxicology-on-a-Chip Platform
Test for toxicity in lung, heart, liver, and vasculature-on-Chip models
SynTox Idealized Linear Chip
SynTox Idealized Radial Chip
SynTox™ is SynVivo’s advanced toxicology-on-a-chip platform, designed for multi-cellular, multi-organ applications including lung, liver, cardiac, and vasculature-on-a-chip models. By recreating native 3D tissue microenvironments with perfused vasculature under dynamic flow and shear stress, SynTox™ enables human-relevant in vitro toxicology testing that delivers more predictive results than traditional 2D systems or animal models.
With real-time optical monitoring, low reagent requirements, vascularized chip designs, and TEER integration, SynTox™ supports early safety screening, mechanistic toxicology, and disease modeling—helping researchers identify drug liabilities and accelerate safer therapeutic development.
Advantages of SynTox™
- Human-relevant 3D toxicology-on-a-chip models
- Vascularized chip designs for physiologic blood flow and vascular toxicology assays
- Dynamic flow-based assays replicate in vivo drug exposure
- Real-time imaging & TEER monitoring for barrier integrity
- Low reagent consumption for scalable and cost-effective workflows
- Supports NAMs and FDA Modernization Act non-animal testing frameworks
With its scalable, reproducible platform, SynTox™ empowers researchers to generate reliable toxicology data for regulatory submissions, mechanistic studies, and next-generation preclinical testing—supporting the global transition toward non-animal testing methods.
Vascular Model
Assess drug induced vascular injury.
Cardiac Model
Drug toxicity on cardiac cells. Left panel indicates viable cells while right panel indicates mixture of live and dead cells following drug treatment.
Lung Model
Lung epithelial oxidative stress can be visualized using SynALI.
Liver Model
Acetaminophen toxicity on hepatocytes following bolus injection. Peripheral hepatocytes show severe toxicity.
Applications and Assays
Publications Using SynTox Models
Contract Research Services using SynTox models
Drug safety testing in lung, liver, heart and vasculature
Models Available
Human Lung-on-Chip
- Lung microvascular endothelial cells, bronchial epithelial cells
- Lung microvascular endothelial cells, alveolar epithelial cells and stroma
Human Liver-on-Chip
Primary hepatocyes (or HepG2) with liver endothelial cells
Human Heart-on-Chip
Co-Culture with Primary aortic endothelial cells, cardiac smooth muscle cells
Human Vasculature-on-Chip
Primary endothelial cells (or HUVECs) in microvascular network or idealized chips
Assays Available
Drug-induced vascular leakage- Test with permeability or TEER
Antibody Drug Conjugate (ADC) screening
Vascular inflammation
Biomarker analysis
Dose-response
Cell viability
Mechanism of action studies
Endpoints
- Permeability
- TEER
- Immune cells adhesion and migration
- Cell proliferation and viability assays
- ROS
- Apoptosis
- Biomarker analysis on chip or from effluents collected
- Omic analysis from cells extracted from chip
- RNAseq, QPCR or WES analysis
Brochures and Technical Manuals
Videos
SynTox™ Product Options & Support
Purchase starter kits, sets of chips, cells/cell lines, instrumentation and training workshops
Starter Kits - Select your chip model
Important Note: Starter kit does not include required consumables such as cells, media, and matrix. Other required equipment not included is syringe pumps, cell seeding pumps, incubators, and microscopes.
The SynTox Starter Kit is the fastest way to begin using SynVivo’s toxicology-on-chip platform. Designed for first-time users, the kit includes all the basic components needed to set up and run SynTox assays with ease.
Kit Contents:
- 12 SynTox™ chips (for lung, liver, or cardiac assays)
- Tubing, clamps, needles, and syringes
- Pneumatic priming device for bubble free functionalized models
- Cell impedance analyzer (TEER configuration only)
This all-in-one package ensures a smooth start to in vitro toxicology testing with reliable, reproducible results.
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Chip Model | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
 | 404002 | $2,415 | |||
 | 404004 | $2,415 |
SynTox Model Chips
SynTox™ Chip Options: Choose the chip architecture that best suits your toxicology application:
- Linear Chips – Ideal for standard toxicology assays and straightforward screening
- Radial Chips – Advanced design enabling complex, multi-cellular, flow-based toxicology studies
Both chip formats recreate 3D human-relevant tissue environments, delivering higher predictive accuracy than traditional 2D systems.
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Chip Model | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
| 102016-STo3 | $425 | |||
| 108013-STo3 | $425 |
Human and Animal Cells/Cell Lines
Toxicity evaluation in liver-on-a-chip systems requires more than hepatocytes alone. Drug-induced liver injury (DILI), fibrosis, metabolic dysfunction, and chronic toxicity all involve interactions between hepatocytes and hepatic stellate cells (HSCs). Together, they recreate a complete toxicity spectrum—early metabolic injury → chronic fibrosis.
Purchasing high-quality human and animal versions of these cells enables researchers to build predictive, physiologically relevant liver models.
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CAT # | Product Name | Price | Qty | |
|---|---|---|---|---|
Syn-10HU-210 | $1,235 | |||
Syn-10HU-233 | $933 | |||
Syn-10HU-210N | $1,312 | |||
Syn-10RA-017 | $609 |
Training Workshops
To help you get the most out of the SynTox toxicology-on-chip platform, SynVivo offers hands-on training programs led by our scientists:
- 2-Day Workshop – Practical introduction to chip operation and assay setup
- 4-Day Workshop – Advanced applications in drug discovery, toxicology studies, and mechanistic modeling
Syringe Pumps - Instrumentation for Seeding Cells and Maintaining Flow Based Assays
SynVivo offers a full suite of compatible organ-on-chip instrumentation to support your toxicology workflows:
- Syringe Pumps – Maintain precise cell seeding and flow conditions
- Stage-Top Incubators – Enable physiologically relevant environments during assays
- Inverted Microscopes – Real-time visualization and quantification of cellular responses
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Image | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
 | 301004 | PHD Ultra 6/10 Multi Syringe Rack | $948 | ||
 | 301020 | Multichannel Programmable Syringe Pump – SynVivo NE 1200 | $2,100 | ||
 | 301002 | Pump 11 Elite Nanomite Infusion/Withdrawal Programmable Single Syringe | $3,790 | ||
 | 301003 | PHD Ultra Syringe Pump Programmable 2-Syringe Rack Standard Pressure | $5,651 |
Tokai Hit Stage Top Incubators
The Tokai Hit incubator offers precision temperature, humidity and CO2 control for long term cell culture on any microscope and optimal conditions for SynVivo’s microfluidic devices.
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Image | CAT# | Product Name | Contact Us |
|---|---|---|---|
 | 303015 | ||
| 303016 | ||
| 303017 |