SynALI™ Lung-on-a-chip model
Morphologically realistic airway structure and environment allowing real-time visualization of cellular and barrier functionality
SynALI Idealized Linear Chip
SynALI™ is SynVivo’s advanced lung-on-a-chip model, engineered around an air–liquid interface (ALI) lung microfluidics platform. Featuring functionalized lung epithelial cells enveloped by a lung microvascular endothelium, SynALI™ creates a physiologically relevant alveolar environment—including ciliary function and mucus secretion—under dynamic flow and shear stress conditions.
SynALI™ Model Highlights
- Air–Liquid Interface Microenvironment – Mimics alveolar architecture with epithelial and endothelial co-culture
- Functional Airway Physiology – Enables live observation of ciliary motility, mucus dynamics, and barrier integrity
- Dynamic Flow & Shear Stress – Accurately replicates in vivo vascular conditions
- Immune & Therapeutic Readouts – Ideal for toxicology, infection, inflammation, and drug efficacy testing
- Aligns with human-relevant, non-animal testing paradigms
Small Airway Lung Model
Co-culture with human bronchial epithelial cells (HBEC) and lung microvascular endothelial cells .
Alveolar Lung Model
Human microvascular lung endothelial cells and alveolar epithelial type I and II cells.
Lumenized Human Lung bronchial epithelial cells (HBEC)
Applications and Assays
Publications, Brochures, and Technical Manuals
Videos
Contract Research Services using SynALI models
Drug safety, toxicity, efficacy assays. Screen in liquid or vapor phase
SynALI Models Available
Human Small Airway Lung Model
- Monoculture using primary human lung bronchial epithelial or microvascular endothelial cells
- Co-Culture with human lung primary bronchial epithelial and microvascular endothelial cells
Human Alveolar Lung Model
- Monoculture using primary human lung alveolar epithelial or microvascular endothelial cells
- Co-Culture with human lung primary alveolar epithelial and microvascular endothelial cells
- Tri-Culture with human lung primary alveolar epithelial, endothelial and fibroblasts.
Assays Available
Toxicity assays
- Viability with Live Dead, apoptosis and ROS assays
- Acute inflammation with immune cell adhesion and migration assays, permeability and TEER
- Vascular injury
Biomarker analysis
- Immunocytochemistry, Cytokine profiing, QPCR
OMIC analysis
- Collect cells or effluents for downstream genomic, transcriptomic, proteomic or metabolomic analysis.
Therapeutic screening
Purchase SynALI Products and Instruments
Purchase starter kits, sets of chips, lung cells/cell lines, instrumentation and training workshops
Starter Kits - Select your chip model
Important Note: Starter kit does not include required consumables such as cells, media, and matrix. Other required equipment not included is syringe pumps, cell seeding pumps, incubators, and microscopes.
SynALI™ Starter Kit: Start your airway-on-a-chip research with ease using the SynALI™ Starter Kit.
Includes:
- Microfluidic SynALI linear or microvascular network ALI chips (12)
- Pneumatic priming device
- Tubing, clamps, needles, and syringes
- Optimized protocols for maintaining the ALI and supporting ciliary and mucus activity
The ALI Model kit features a disposable, optically transparent chip that supports mucus transport, airway tubule formation, ciliary beating, and immune cell assays, all visualized in real time.
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Chip Model | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
 | 405001 | $2,415 |
SynALI Model Chip
SynALI™ Chip Option: The linear chip architecture best suits your air-liquid interface application:
- Linear Chip – Ideal for Drug safety, toxicity, and efficacy assays
The linear chip format recreates 3D human-relevant tissue environments, delivering higher predictive accuracy than traditional 2D systems.
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Chip Model | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
| 108011-SA3 | $425 |
Human Cells/Cell Lines
Cells & Cell Lines: SynVivo provides validated options for enhanced study fidelity:
- Primary human lung epithelial cells and microvascular endothelial cells
- Co-culture with immune cells (e.g., macrophages, neutrophils) to model respiratory diseases
- Custom cell sourcing available for disease-specific or translational studies
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CAT # | Product Name | Price | Qty | |
|---|---|---|---|---|
Syn-10HU-029 | $888 | |||
Syn-10HU-076 | $897 | |||
Syn-10HU-123 | $901 |
Training Workshops
Training Workshops: Accelerate proficiency with SynVivo’s expert-led programs:
- 2-Day Intro Workshop – Focused on setup, ALI maintenance, and basic functional assays
- 4-Day Advanced Workshop – Covers immune interaction assays, mucus and ciliary function, drug testing workflows, and mechanistic modeling
Syringe Pumps - Instrumentation for Seeding Cells and Maintaining Flow Based Assays
Instrumentation: Ensure high-quality results with SynVivo-compatible tools:
- Syringe pumps for precise flow control
- Stage-top incubators and inverted microscopes for real-time imaging of ciliary beating, mucus flow, and drug deliver
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Image | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
 | 301004 | PHD Ultra 6/10 Multi Syringe Rack | $948 | ||
 | 301020 | Multichannel Programmable Syringe Pump – SynVivo NE 1200 | $2,100 | ||
 | 301002 | Pump 11 Elite Nanomite Infusion/Withdrawal Programmable Single Syringe | $3,790 | ||
 | 301003 | PHD Ultra Syringe Pump Programmable 2-Syringe Rack Standard Pressure | $5,651 |
Tokai Hit Stage Top Incubators
The Tokai Hit incubator offers precision temperature, humidity and CO2 control for long term cell culture on any microscope and optimal conditions for SynVivo’s microfluidic devices.
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Image | CAT# | Product Name | Contact Us |
|---|---|---|---|
 | 303015 | ||
| 303016 | ||
| 303017 |