SynRAM Inflammation-on-a-Chip
Study the entire inflammation pathway in a realistic and dynamic environment
SynRAM Idealized Radial Chip
SynRAM Microvascular Network Chip
SynRAM™ delivers a physiologically realistic inflammation model (including flow and shear stress) and enables real-time visualization and quantitation of rolling, adhesion and migration processes in the leukocyte adhesion cascade. Key features of this model include in vivo-like microvascular morphology with fully formed lumenized blood vessels, physiological flow, co-culture capability for endothelial-immune cell interactions and quantitative analysis of rolling, adhesion, and migration data from a single experiment. SynRAM has been successfully validated against in vivo studies showing excellent correlation for rolling velocities, adhesion patterns, and migratory processes.
SynRAM inflammation-on-a-Chip model has been used to test drug or inflammation induced vascular injury, screen anti-inflammatory therapeutics and to model disease conditions like Sepsis and Acute Respiratory Distress Syndrome (ARDS).
Real-time visualization of rolling, adhesion and migration
Real-time tracking of single-cell migration
Leukocyte endothelium interactions
Vessel-on-a-Chip with endothelial cells
Applications and Assays
Publications using SynRAM models
Contract Research Services using SynRAM models
Model Inflammation, immune cell-endothelial interactions, test drug safety
SynRAM Models Available
Monoculture using primary or iPSC derived endothelial cells
- Specific organ matched endothelial cells or HUVECs
Co-Culture with endothelial cells and stromal/tissue cells
- Lung microvascular endothelial cells and epithelial cells
- Brain microvascular endothelial cells and astrocytes/pericytes
Add immune cells to any model
Assays Available
Immune cell rolling, adhesion and migration across the endothelium
Inflammation-induced vascular permeability
Drug-induced vascular injury
Inflammation-induced biomarker analysis, cytokine profiling
Therapeutic drug screening
Screening for cell surface biomarkers
Target identification
Screening for activators/inhibitors of inflammation
Brochures and Technical Manuals
Videos
Purchase SynRAM Products and Instruments
Purchase starter kits, sets of chips, cells/cell lines, instrumentation and training workshops
SynRAM Starter Kit: Select this for your first-time purchase. All the basic components required to run SynRAM assays can be purchased in a kit format. The SynRAM starter kit includes 12 chips, tubing, clamps, needles, syringes, pneumatic priming device (required for seeding cells).
Cells/Cell Lines: SynVivo offers human cells and cell lines that have been tested and validated in the inflammation model.
SynRAM Chip Options: Depending on your specific research applications you can select from Idealized Network or Microvascular Network configurations.
Instrumentation: Syringe Pumps for cell seeding and maintaining flow based assays, stagetop Incubator and inverted microscope for real time visualization and quantitation of your Tumor assays
Training Workshops: SynVivo offers 2 and 4 day scientist-led training sessions. Gain hands-on experience with our organ-on-a-chip technology.
Starter Kits - Select your chip model
Important Note: Starter kit does not include required consumables such as cells, media, and matrix. Other required equipment not included is syringe pumps, cell seeding pumps, incubators, and microscopes.
Filters Sort results
Reset Apply
Chip Model | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
 | 401002 | $2,100 | |||
 | 401004 | $2,500 |
SynRAM Model Chips
Filters Sort results
Reset Apply
Chip Model | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
| 102008-SR3 | $375 | |||
| 105001-SR3 | $499 |
Human Cells/Cell Lines
Filters Sort results
Reset Apply
CAT # | Product Name | Price | Qty | |
|---|---|---|---|---|
Syn-10HU-003-CR10M | $141 | |||
Syn-10HU-003-CR350M | $894 | |||
Syn-10HU-003-CR5M | $78 | |||
Syn-10HU-003-P | $197 | |||
Syn-CXPR-15-1200M | $2,020 | |||
Syn-CXPR-15-200M | $1,006 | |||
Syn-10HU-009-20M | $872 | |||
Syn-10HU-008N-10M | $1,086 | |||
Syn-10HU-024N-5M | $599 |
Training Workshops
Syringe Pumps - Instrumentation for Seeding cells and maintaining Flow based assays
Filters Sort results
Reset Apply
Image | CAT# | Product Name | Price | Qty | |
|---|---|---|---|---|---|
 | 301004 | PHD Ultra 6/10 Multi Syringe Rack | $920 | ||
 | 301020 | Multichannel Programmable Syringe Pump – SynVivo NE 1200 | $2,100 | ||
 | 301002 | Pump 11 Elite Nanomite Infusion/Withdrawal Programmable Single Syringe | $3,790 | ||
 | 301003 | PHD Ultra Syringe Pump Programmable 2-Syringe Rack Standard Pressure | $5,651 |
Tokai Hit Stage Top Incubator
Filters Sort results
Reset Apply
Image | CAT# | Product Name | Contact Us |
|---|---|---|---|
 | 303015 | ||
| 303016 | ||
| 303017 |