Use of Transwells for migration experiments have shown that these static assays are difficult to use, often have repeatability issues, and do not provide as much quantitative data as desired. Imagine an assay that is repeatable, simple to use, provides real-time live-cell imaging and gives data that matches in vivo observations. SynVivo has overcome the limitations of Transwell® assays to provide an entirely new system for studying migration in a realistic and dynamic environment.
By emulating a histological slice of co-cultured tumor or tissue cells with lumen of endothelial cells, the SynVivo platform delivers a physiologically realistic model including flow and shear in a platform that enables real-time tracking of migration processes.