A Physiological Microfluidic Platform for Toxicity Analysis
Live Webinar on Thursday April 30th 1:00pm PDT / 4:00pm EDT
Drug induced toxicity is the major reason for failure of therapeutics in preclinical and clinical trials.
In addition, environmental toxicity is a significant concern for several pathological conditions.
Widely used static well plate assays and commercially available in vitro fluidic devices suffer from several limitations for studying the physiological conditions in vivo. These include,
- lack of critical morphological features (e.g., bifurcations, tortuosity),
- inability to distinguish between healthy vs. diseased vasculature,
- large consumable volumes and
- inability to support co-cultures.
To overcome these limitations, we have developed a patented microfluidic cell based platform: SynVivo® which comprises of idealized and in vivo derived microvascular networks patterned onto a plastic, disposable substrate to mimic the morphological and physiological conditions observed in vivo. Cells (e.g., endothelial, tumor, tissue) can be readily grown in the device in mono culture or co-culture conditions, thereby enabling cell-drug interaction studies in the most in vivo like environment.
In this presentation, SynVivo CTO Dr. Prabhakar Pandian will present applications of the SynVivo platform for physiological responses focusing on cell-particle interactions, inflammation and toxicity.
This webinar is free to qualifying participants. Simply fill out the form below and we will confirm and send the webinar link.