The following publications contain useful information about SynVivo technology and applications. Follow the doi links to see the abstracts and to obtain copies of the papers. Let us know if you have published a peer reviewed article utilzing SynVivo and we can add it to the list.



Trastuzumab Distribution in an In-Vivo and In-Vitro Model of Brain Metastases of Breast Cancer Tori B. Terrell-Hall, Mohamed Ismail Nounou, Fatema El-Amrawy, Jessica I.G. Griffith and Paul R. Lockman Oncotarget. 2017; 8:83734-83744

A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems  Yuan Tang, Fariborz Soroush, Joel B. Sheffield, Bin Wang, Balabhaskar Prabhakarpandian & Mohammad F. Kiani Scientific Reports 7, Article number: 9359 (2017)
DOI 10.1038/s41598-017-09815-9

Permeability across a novel microfluidic blood‑tumor barrier model. Tori B. Terrell‑Hall , Amanda G. Ammer , Jessica I. G. Griffith and Paul R. Lockman  Fluids and Barriers of the CNS (2017) 14:3
DOI 10.1186/s12987-017-0050-9

A novel microfluidic assay reveals a key role for protein kinase C δ in regulating human neutrophil-endothelium interaction. Soroush F, Zhang T, King DJ, Tang Y, Deosarkar S, Prabhakarpandian B, Kilpatrick LE, Kiani MF. J Leukoc Biol November 2016 100:10271035.
DOI: 10.1189/jlb.3MA0216-087R


A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip. S. Deosarkar, B. Prabhakarpandian, B. Wang, J.B. Sheffield, B. Krynska, M. Kiani. PLOS ONE, 2015

Adhesion Patterns in the Microvasculature are Dependent on Bifurcation Angle. G. Lamberti, F. Soroush, A. Smith, M. Kiani, B. Prabhakarpandian, K. Pant. Microvascular Res., 2015, 99, pp 19-25


Expanding Imaging Capabilities for Microfluidics: Applicability of Darkfield Internal Reflection Illumination (DIRI) to Observations in Microfluidics. Y. Kawano, C. Otsuka, J. Sanzo, C. Higgins, T. Nirei, T. Schilling, T. Ishikawa. PLoS ONE, 2015, 10(3): e0116925

Synthetic Tumor Networks for Screening Drug Delivery Systems. B. Prabhakarpandian, MC Shen, J. Nichols, C. Garson, I. Mills, M. Matar, J. Fewell, K. Pant. J Control Release., 2015, 201, 49-55

Bioinspired Microfluidic Assay for In Vitro Modeling of Leukocyte–Endothelium Interactions. G. Lamberti, B. Prabhakarpandian, C. Garson, A. Smith, K. Pant, B. Wang, and M.F. Kiani. Anal. Chem., 2014, 86 (16), pp 8344–8351

Generation of Shear Adhesion Map Using SynVivo Synthetic Microvascular Networks. Smith, A. M., Prabhakarpandian, B., Pant, K. J. Vis. Exp. (87), e51025, 2014

Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium. Kolhara P, Anselmob AC, Guptab V, Pant K, Prabhakarpandian B, Ruoslahtid E, and Mitragotri S. PNAS 2013

Adhesive Interaction of Functionalized Particles and Endothelium in Idealized Microvascular Networks. G. Lamberti, Y. Tang, B. Prabhakarpandian, Y. Wang, K. Pant, M.F, Kiani, B. Wang. Microvascular Res. 2013 (89) pp 107-114

SyM-BBB: A Microfluidic Blood Brain Barrier Model B. Prabhakarpandian, M.-C. Shen, J.B. Nichols, I.R. Mills, M.S.-Wegrzynowicz, M. Aschner, K. Pant, Lab on a Chip, 2013, 13, 1093-1101

Microfluidic devices for modeling cell-cell and particle-cell interactions in the microvasculature. Prabhakarpandian B, Shen MC, Pant K, Kiani MF. Microvasc Res. 2011 Nov;82(3):210-20

Bifurcations: focal points of particle adhesion in microvascular networks. Prabhakarpandian B, Wang Y, Rea-Ramsey A, Sundaram S, Kiani MF, Pant K. Microcirculation. 2011 Jul;18(5):380-9

Flow and adhesion of drug carriers in blood vessels depend on their shape: a study using model synthetic microvascular networks. Doshi N, Prabhakarpandian B, Rea-Ramsey A, Pant K, Sundaram S, Mitragotri S. J Control Release. 2010 Sep 1;146(2):196-200

Preferential adhesion of leukocytes near bifurcations is endothelium independent. Tousi N, Wang B, Pant K, Kiani MF, Prabhakarpandian B. Microvasc Res. 2010 Dec;80(3):384-8

A physiologically realistic in vitro model of microvascular networks. Rosano JM, Tousi N, Scott RC, Krynska B, Rizzo V, Prabhakarpandian B, Pant K, Sundaram S, Kiani MF. Biomed Microdevices. 2009 May 19

Synthetic microvascular networks for quantitative analysis of particle adhesion. Prabhakarpandian B, Pant K, Scott RC, Patillo CB, Irimia D, Kiani MF, Sundaram S. Biomed Microdevices. 2008 Aug;10 (4):585-95