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SynVivo used to create the first neonatal blood-brain barrier model on a chip
Researchers at Temple University used the SynVivo® cell-based in vitro assay platform to model the attributes and functions of the neonatal stage blood-brain barrier (BBB). The SynVivo BBB model closely mimics the in vivo microenvironment including three-dimensional morphology, cellular interactions and flow characteristics on a microfluidic chip. This work marks the first dynamic in vitro neonatal BBB model that offers real time visualization and analysis and is suitable for studies of BBB function as well as screening of novel therapeutics.
SynVivo Tumor Assay Featured on the Cover of J Controlled Release
We are proud that the editors of the Journal of Controlled Release have selected a new paper from SynVivo CTO, Prabhakar Pandian, Ph.D, and his colleagues as the cover of this prestigious journal publication. The paper describes the team’s work to reproduce a realistic and dynamic tumor microenvironment and it’s use in screening drug delivery systems. The studies were performed using the SynVivo co-culture microfluidic cell-based assay device whereby they created an in vitro tumor microenvironment encompassing circulatory flow in the vessels, transport across the leaky vasculature near the tumor region and real-time visualization of drug deliver to 3D culture of tumor cells.
Leukocyte Rolling, Adhesion, and Migration in a Single Assay!
Leukocytes play a key role in early response to tissue injury/infection resulting from physical, chemical or biological stimuli. This process involves the initiation of the leukocyte adhesion cascade mediated by a series of interactions between receptors and ligands on the endothelium and the leukocytes. Specifically, circulating leukocytes tether and roll along the vessel wall by establishing transient (selectin-mediated) interactions with endothelial cells followed by (integrin-mediated) firm adhesion with eventual migration across the endothelial cells to the extra-vascular space.
Let Us Help You Equip Your Microfluidic Lab
Our history of developing and using the SynVivo® microfluidic platform has allowed us to test and evaluate the associated instruments needed to perform reliable and repeatable cell-based assays. This experience has led us to identify and design the best equipment to ensure success in your research. We offer specific support and training on how to get the most out of the equipment in your lab. The turn-key solution for performing SynVivo assays comprises of a Nikon Ti microscope system, a Harvard Apparatus syringe pump(s) and a custom designed stage top incubator developed in collaboration with In Vivo Scientific.
AWARD! Top 10 Innovations of 2013 by The Scientist Magazine
The SynVivo® microfluidic cell-based assay platform has been recognized as one of the “Top 10 Innovations of 2013” by The Scientist magazine. SynVivo enables faster, more efficient drug development by combining the control of in vitro testing with the realism of in vivo studies.
Kids are Different: A Pediatric BBB Model
Researchers at Temple University are using the SynVivo platform to develop an in vitro BBB model, that mimics both functionally and anatomically the pediatric brain microvasculature. Funded by the Shriners Hospitals for Children, the long term goal of this project is to effectively screen delivery vehicles and therapeutics for pediatric brain disorders.
Nanoparticle Shapes Affect Drug Delivery
It is well known that nanoparticles can be effective transport vehicles to enhance drug delivery. However, recent work by the Mitragotri Lab at the University of California Santa Barbara has shown that not all nanoparticles behave the same. In fact it is not just the size of the particles but more importantly their shape that can be a determining factor in success or failure for delivery.
A Better Model for the Blood-Brain Barrier
Current techniques for mimicking the Blood–Brain Barrier (BBB) largely use incubation chambers (Transwell) separated with a filter and matrix coating to represent and to study barrier permeability. These devices have several critical shortcomings:
- They do not reproduce critical microenvironmental parameters, primarily anatomical size or hemodynamic shear stress,
- They often do not provide real-time visualization capability, and
- They require a large amount of consumables