SynVivo-Chip

Microfluidic Chips

SynVivo is a cell based microfluidic chip that enables shorter and more successful drug development by combining the efficiency and control of in vitro testing with the realism and validation of in vivo studies. SynVivo biochips are readily available as standard stock items. We are also capable of producing any custom designed chip and morphology as needed.

The SynVivo platform can support custom assays based on your research application. Don’t see a catalog assay for your biological question?  Want to perform your assay using a linear chip design? We can develop a custom assay kit for you using our library of chip designs- See more information in the following tabs.

  • Linear Channels
  • Bifurcating Channels
  • Microvascular Networks
  • Idealized Networks

Custom Designs – If you need a specialized microvasulature or other design we have the necessary equipment to fabricate most any design based on your research needs. Our engineers will work with you to help design the most relevant SynVivo channel or network configuration to help you achieve your research goals.

linearUse Linear Channels for studying cell/particle adhesion and cell-cell or cell-particle interactions at the micro-circulation scale. Use as a substitute for parallel plate flow chambers for >90% savings in consumables.

Linear Channels Design Library

Three channels per chip of various widths to allow you to study shear effects based on channel size and flow rates.

IMN1-LC

Standard Width Options (W1 / W2 / W3):

  • 100 μm / 100 μm / 100 μm
  • 250 μm / 250 μm / 250 μm
  • 500 μm / 500 μm / 500 μm
  • 100 μm / 250 μm / 500 μm

Custom designs/sizes also available.

Cat#
Product Name
Price
101001
Linear Channel Chip (3×100μm)
101002
Linear Channel Chip (3×250μm)
101003
Linear Channel Chip (3×500μm)
101004
Linear Channel Chip (100/250/500μm)

Note: Does not include other required consumables such as tubing, clamps, syringes, needles, cells, media and matrix.
Laboratory equipment required includes incubators, inverted microscopes, and syringe pumps.

bifurcatingUse symmetric and asymmetric bifurcations to study cell/particle adhesion and cell-cell or cell-particle interactions at bifurcations and to study the effect of the bifurcation angle and asymmetry on adhesion. Compare adhesion in linear sections and bifurcations simultaneously.

Bifurcating Channels Design Library

With various options of symmetric and asymmetric bifurcating angles and parent/daughter channel widths you can likely find a set of designs to provide you the best models for your research.

IMN1-BC

Standard Symmetric Bifurcation Angle (θBC) Options:

  • 15° + 15°
  • 30° + 30°
  • 45° + 45°
  • 60° + 60°

Custom designs/sizes also available.

Cat#
Product Name
Price
101005
Bifurcating Channel Chip (30° Sym)
101006
Bifurcating Channel Chip (60° Sym)
101007
Bifurcating Channel Chip (90° Sym)
101008
Bifurcating Channel Chip (120° Sym)

Note: Does not include other required consumables such as tubing, clamps, syringes, needles, cells, media and matrix.
Laboratory equipment required includes incubators, inverted microscopes, and syringe pumps.

microvascular-networkUse Microvascular Networks to replicate in vivo cell/particle adhesion and cell-cell or cell-particle interactions in an in vitro setting. Investigate effects of flow and morphology for drug delivery, drug discovery and cellular behavior. Obtain shear-adhesion maps and bifurcation vs. branch adhesion in single experiment.

Microvascular Network Design Library

104001
SMN1-C001 (104001)

$79 Add to cart

104002
SMN1-D001 (104002)

$79 Add to cart

104003
SMN1-C002 (104003)

$79 Add to cart

104004
SMN1-C003 (104004)

$79 Add to cart

104005
SMN1-C004 (104005)

$79 Add to cart

104006
SMN1-C005 (104006)

$79 Add to cart

104007
SMN1-C006 (104007)

$79 Add to cart

104008
SMN1-C007 (104008)

$79 Add to cart

104009
SMN1-D002 (104009)

$79 Add to cart

104010
SMN1-D003 (104010)

$79 Add to cart

104011
SMN1-D004 (104011)

$79 Add to cart

104012
SMN1-D005 (104012)

$79 Add to cart

104013
SMN1-D006 (104013)

$79 Add to cart

104014
SMN1-D007 (104014)

$79 Add to cart

co-culture-networkUse network co-culture assays to replicate the in vivo physiological and morphological conditions in addition to desired cellular makeup.

Co-Culture Network Design Library

By incorporating natural tissue regions within the network topology, the co-culture networks allow study of cell and drug behavior at and across the interfaces. The co-culture network constructs are available with several options for channel size, tissue region scaffolding, and barrier design. We can help you select the right parameters for your needs and can also construct custom designs if needed.

SMN2-SMN3-1
SMN2-C001 (105001)

$129 Add to cart

SMN2-SMN3
SMN2-D001 (105002)

$129 Add to cart

co-culture-idealized Use idealized co-culture assays to mimic the cellular make up in vivo. Investigate cell-cell interactions and perfusion vs. diffusion based affects. Analyze the experiments in real-time for all the cell populations.

Co-Culture Design Library

Intended to mimic the formation of and transport across tight and gap junctions such as the blood-brain barrier and other endothelial/tissue interfaces, the idealized co-culture constructs are available with several options for channel size, tissue chamber size and scaffolding, and barrier design. We can help you select the right parameters for your needs and can also construct custom designs if needed. Please contact us for details.

Slit Barrier Option

This device utilizes slits and gaps to form the barrier region between the outer channel and inner chamber.

Standard design parameters available are:

  • Outer Channel Width (OC): 100 μm or 200 μm
  • Travel Width (T): 50 μm or 100 μm
  • Slit Spacing (SS): 50 μm or 100 μm
  • Slit Width (WS): Variable
idealized1

IMN2/IMN3 (Slits)

MN2/IMN3 Chamber Zoom

IMN2/IMN3 Chamber Zoom

IMN2/IMN3 Slit Details

IMN2/IMN3 Slit Details

Cat#
Product Name
Price
102005
Idealized Co-Culture Network Chip (3μm slits, 50μm travel)
102006
Idealized Co-Culture Network Chip (3μm slits, 100μm travel)
102016
Idealized Co-Culture Network Chip (2μm slits, 50μm travel)
102017
Idealized Co-Culture Network Chip (2μm slits, 100μm travel)

Note: Does not include other required consumables such as tubing, clamps, syringes, needles, cells, media and matrix.
Laboratory equipment required includes incubators, inverted microscopes, and syringe pumps.

Pillar Barrier Option

This device utilizes pillars to form the barrier region between the outer channel and inner chamber.

Standard design parameters available are:

  • Outer Channel Width (OC): 100μm or 200μm
  • Travel Width (T): 50 μm or 100μm
  • Pillar Spacing (Gap) (SP): 8μm or 3μm
  • Pillar Diameter (DP): Variable
  • Pore sizes available 3μm or 8μm
idealized1

IMN2/IMN3 (Pillars)

MN2/IMN3 Chamber Zoom

IMN2/IMN3 Chamber Zoom

IMN2/IMN3 Slit Details

IMN2/IMN3 Pillar Details

Cat#
Product Name
Price
102008
Idealized Co-Culture Network Chip (Pillars, 3μm Pore)
102012
Idealized Co-Culture Network Chip (Pillars, 8μm Pore)

Note: Does not include other required consumables such as tubing, clamps, syringes, needles, cells, media and matrix.
Laboratory equipment required includes incubators, inverted microscopes, and syringe pumps.